Friday July 2, 2010

Q: You confirmed propofol infusion syndrome in a patient on prolong high concentration infusion. Once you stop propofol how long does it take to recover from propofol associated lactic acidosis?


Answer: About 6 hours

Propofol infusion syndrome (PRIS) has been observed in patients receiving propofol at high dosages and for prolonged periods though reported with lower doses as well as short infusion time. It is said to be synergestic when given concomitantly with catecholamines or steroids in the setting of acute neurologic or inflammatory diseases.
Propofol infusion syndrome is said to occur in patients with genetic mitochondrial abnormalities.

MCQ on PRIS here (posted here earlier)